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As of [update] about , people in Southeastern Michigan trace their descent from the Middle East. As of [update] , almost 8, Hmong people lived in the State of Michigan, about double their presence in the state. The state has Japanese employment facilities providing 35, local jobs. The Japanese Direct Investment Survey of the Consulate-General of Japan, Detroit stated more than 2, additional Japanese residents were employed in the State of Michigan as of 1 October [update] , than in A person from Michigan is called a Michigander or Michiganian; [67] also at times, but rarely, a "Michiganite".

As of [update] , In total, 8. When Michigan became a state in , the boundary of the Diocese of Detroit was redrawn to coincide with that of the State; the other dioceses were later carved out from the Diocese of Detroit but remain part of the Ecclesiastical Province of Detroit. In , the largest Protestant denominations were the United Methodist Church with , adherents; followed by the Lutheran Church—Missouri Synod with ,, and the Evangelical Lutheran Church in America with , adherents.

The Christian Reformed Church in North America had almost , members and more than congregations in Michigan. In West Michigan, Dutch immigrants fled from the specter of religious persecution and famine in the Netherlands around and settled in and around what is now Holland, Michigan, establishing a "colony" on American soil that fervently held onto Calvinist doctrine that established a significant presence of Reformed churches.

Battle Creek, Michigan, is also the birthplace of the Seventh-day Adventist Church , which was founded on May 21, Source : Fortune [95]. In , 3,, people in Michigan were employed at , establishments, according to the U. Census Bureau. The U. Products and services include automobiles, food products, information technology, aerospace, military equipment, furniture, and mining of copper and iron ore. Faygo was founded in Detroit on November 4, Michigan became the 24th right-to-work state in U.

Since , GM, Ford and Chrysler have managed a significant reorganization of their benefit funds structure after a volatile stock market which followed the September 11 attacks and early s recession impacted their respective U. Manufacturing in the state grew 6. In , GM and Chrysler emerged from Chapter 11 restructurings with financing provided in part by the U. As of [update] , Michigan ranked fourth in the U. The domestic auto industry accounts directly and indirectly for one of every ten jobs in the U.

Michigan was second in the U. From to , Michigan was the only state to top the 10, mark for the number of major new developments; [28] [] however, the effects of the late s recession have slowed the state's economy. In , Michigan placed third in a site selection survey among the states for luring new business which measured capital investment and new job creation per one million population.

Department of Energy for the manufacture of electric vehicle technologies which is expected to generate 6, immediate jobs and employ 40, in the state by Michigan's workforce is well-educated and highly skilled, making it attractive to companies. It has the third highest number of engineering graduates nationally. Detroit Metropolitan Airport is one of the nation's most recently expanded and modernized airports with six major runways, and large aircraft maintenance facilities capable of servicing and repairing a Boeing and is a major hub for Delta Air Lines.

Michigan's schools and colleges rank among the nation's best. The state has maintained its early commitment to public education. The state's infrastructure gives it a competitive edge; Michigan has 38 deep water ports. Michigan led the nation in job creation improvement in Michigan's personal income tax is a flat rate of 4. Property taxes are appealable to local boards of review and need the approval of the local electorate to exceed millage rates prescribed by state law and local charters.

A wide variety of commodity crops, fruits, and vegetables are grown in Michigan, making it second only to California among U. Leading crops include corn, soybeans, flowers, wheat, sugar beets, and potatoes. Livestock in the state included 78, sheep, a million cattle, a million hogs, and more than three million chickens. Michigan is a leading grower of fruit in the U. These fruits are mainly grown in West Michigan due to the moderating effect of Lake Michigan on the climate.

There is also significant fruit production, especially cherries, but also grapes, apples, and other fruits, in Northwest Michigan along Lake Michigan. Michigan produces wines , beers and a multitude of processed food products.

Kellogg's cereal is based in Battle Creek, Michigan and processes many locally grown foods. Michigan is home to very fertile land in the Saginaw Valley and Thumb areas. Products grown there include corn, sugar beets, navy beans, and soybeans. Sugar beet harvesting usually begins the first of October. It takes the sugar factories about five months to process the 3. Potatoes are grown in Northern Michigan, and corn is dominant in Central Michigan.

Alfalfa, cucumbers, and asparagus are also grown. The forests, lakes and thousands of miles of beaches are top attractions. In , the Michigan State Board of Education mandated all public schools in the state hold their first day of school after Labor Day, in accordance with the new Post Labor Day School law.

Hunting and fishing are significant industries in the state. Charter boats are based in many Great Lakes cities to fish for salmon, trout, walleye, and perch. More than three-quarters of a million hunters participate in white-tailed deer season alone. Many school districts in rural areas of Michigan cancel school on the opening day of firearm deer season, because of attendance concerns.

Michigan's Department of Natural Resources manages the largest dedicated state forest system in the nation. Public hiking and hunting access has also been secured in extensive commercial forests. The state has the highest number of golf courses and registered snowmobiles in the nation.

The state has numerous historical markers , which can themselves become the center of a tour. Lawrence River. With its position in relation to the Great Lakes and the countless ships that have foundered over the many years they have been used as a transport route for people and bulk cargo, Michigan is a world-class scuba diving destination. The Michigan Underwater Preserves are 11 underwater areas where wrecks are protected for the benefit of sport divers. In , Michigan consumed , gigawatt-hours GWh of electrical energy and produced , gigawatt-hours GWh of electrical energy.

Coal power is Michigan's leading source of electricity, producing roughly half its supply or 53, gigawatt-hours GWh of electrical energy The lower price of natural gas is leading to the closure of most coal plants, with Consumer Energy planning to close all of its remaining coal plants by ; [] DTE plans to retire MW of coal power by Nuclear power is also a significant source of electrical power in Michigan, producing roughly one-quarter of the state's supply or 28, gigawatt-hours GWh of electrical energy 4.

Donald C. Cook Nuclear Plant , just north of Bridgman , is the state's largest nuclear power plant , with a net capacity of 2, MW. It is also one of the two nuclear power plants in the Detroit metropolitan area within a mile radius of Detroit's city center , about halfway between Detroit and Toledo, Ohio , the other being the Davis—Besse Nuclear Power Station , in Ottawa County, Ohio.

The Gordie Howe International Bridge , a second international bridge between Detroit and Windsor, is under construction. It is expected to be completed in These are augmented by several dozen short line railroads. The vast majority of rail service in Michigan is devoted to freight , with Amtrak and various scenic railroads the exceptions.

Amtrak passenger rail services the state, connecting many southern and western Michigan cities to Chicago, Illinois. The Detroit Metropolitan Airport in the western suburb of Romulus , was in the 16th busiest airfield in North America measured by passenger traffic. Ford International Airport in Grand Rapids is the next busiest airport in the state, served by eight airlines to 23 destinations. Flint Bishop International Airport is the third largest airport in the state, served by four airlines to several primary hubs.

Additionally, smaller regional and local airports are located throughout the state including on several islands. Half the wealthiest communities in the state are in Oakland County, just north of Detroit. Another wealthy community is just east of the city, in Grosse Pointe. Only three of these cities are outside of Metro Detroit.

Michigan's education system serves 1. More than , students attend private schools and an uncounted number are homeschooled under certain legal requirements. The University of Michigan is the oldest higher-educational institution in the state, and among the oldest research universities in the nation. It was founded in , 20 years before Michigan Territory achieved statehood.

With an enrollment of 21, students, Baker College is Michigan's largest private post-secondary institution. Motown Motion Picture Studios with , square feet 49, m 2 produces movies in Detroit and the surrounding area based at the Pontiac Centerpoint Business Campus. Michigan's major-league sports teams include: Detroit Tigers baseball team, Detroit Lions football team, Detroit Red Wings ice hockey team, and the Detroit Pistons men's basketball team.

All of Michigan's major league teams play in the Metro Detroit area. In , the team moved to the newly built Little Caesars Arena in downtown Detroit. The Detroit Lions played at Tiger Stadium in Detroit until , then moved to the Pontiac Silverdome where they played for 27 years between and before moving to Ford Field in Detroit in In they moved to Comerica Park.

They later moved to Little Caesars Arena to join the Pistons as tenants in Professional hockey got its start in Houghton , [] when the Portage Lakers were formed. Wieber was also a member of the gold medal team at the London Olympics in Collegiate sports in Michigan are popular in addition to professional sports. Michigan Stadium in Ann Arbor, home to the Michigan Wolverines football team, is the largest stadium in the Western Hemisphere and the third-largest stadium worldwide.

Michigan is traditionally known as "The Wolverine State", and the University of Michigan takes the wolverine as its mascot. The association is well and long established: for example, many Detroiters volunteered to fight during the American Civil War and George Armstrong Custer , who led the Michigan Brigade, called them the "Wolverines".

The origins of this association are obscure; it may derive from a busy trade in wolverine furs in Sault Ste. Marie in the 18th century or may recall a disparagement intended to compare early settlers in Michigan with the vicious mammal. Wolverines are, however, extremely rare in Michigan. A sighting in February near Ubly was the first confirmed sighting in Michigan in years. From Wikipedia, the free encyclopedia. This article is about the U. For other uses, see Michigan disambiguation.

For states around the Great Lakes region, see Great Lakes region. State in the United States. Si quaeris peninsulam amoenam circumspice English: "If you seek a pleasant peninsula, look about you". Mount Arvon [3] [a]. Lake Erie [3] [a]. See also: Timeline of Michigan history and History of Michigan. Territorial changes of the Michigan Territory from to Main article: Government of Michigan.

Main article: Law of Michigan. Main article: Politics of Michigan. Main article: Administrative divisions of Michigan. See also: List of counties in Michigan and List of municipalities in Michigan. Largest cities or towns in Michigan Census : [40].

See also: Climate change in Michigan. See also: Michigan statistical areas. See also: List of companies based in Michigan , Economy of metropolitan Detroit , and Michigan locations by per capita income. See also: Cherry production in Michigan. See also: List of power stations in Michigan.

See also: List of Michigan railroads and History of railroads in Michigan. Main article: Michigan Services. See also: List of airports in Michigan. Further information: List of cities, villages, and townships in Michigan. See also: List of colleges and universities in Michigan and List of high schools in Michigan. University of Michigan. Main article: Music of Michigan. Main article: List of Michigan professional sports teams.

See also: List of Michigan sport championships. State nicknames : Wolverine State , Great Lake State , Mitten State , Water-Winter Wonderland State motto : Si quaeris peninsulam amoenam circumspice Latin: "If you seek a pleasant peninsula, look about you" adopted in on the coat-of-arms, but never as an official motto.

This is a paraphrase of the epitaph of British architect Sir Christopher Wren about his masterpiece, St. Paul's Cathedral. It is composed of fossilized coral Hexagonaria pericarnata from long ago when the middle of the continent was covered with a shallow sea. State gem : Isle Royale greenstone since Also called chlorastrolite literally "green star stone" , the mineral is found on Isle Royale and the Keweenaw peninsula.

State quarter : U. State soil : Kalkaska sand since , ranges in color from black to yellowish brown, covers nearly 1,,acre 4, km 2 in 29 counties. Michigan portal Michigan highways portal. Georgia is the largest state by land area alone east of the Mississippi and Michigan the second-largest.

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Archived from the original on January 2, Another nickname for Michigan is the "Great Lake State". Michigan's shores touch four of the five Great Lakes, and Michigan has more than 11, inland lakes. In Michigan, you are never more than six miles from an inland lake or more than 85 miles from a Great Lake. National Weather Service. Archived from the original on November 9, Retrieved June 1, Retrieved March 20, Archived from the original on July 6, Retrieved April 12, Retrieved November 1, Archived from the original on May 3, Retrieved May 3, Archived from the original on April 29, Retrieved April 5, Archived from the original on July 25, Retrieved December 11, August 12, Retrieved August 12, Retrieved December 22, Archived from the original on October 5, Retrieved May 5, Southeastern Michigan has about , people who trace their roots to the Middle East.

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Retrieved April 17, Archived from the original PDF on July 16, Archived from the original on January 16, Archived from the original on April 21, Crain's Detroit Business. In the left panel, confocal immunofluorescent localization of S proteins green signal and CD11b red signal.

Colocalization of the markers on confocal images of cells yellow signal. Nuclei are stained by DAPI blue signal. In the central and right panels, immunochemical localization of S proteins in the cells. The black and red arrows indicate macrophages and a dendritic cell, respectively, with increased production of S proteins. Figure 13 Confocal immunofluorescent localization of vimentin green signal and CD11b red signal in the cells in a fragment of a mouse splenic granuloma.

Colocalization of the markers on the confocal images of cells yellow signal. Macrophages with BCG-mycobacteria reproducing in them are indicated by the white arrows on the fluorescent images and the black arrows on the ZN image. Published figure using CD11b monoclonal antibody Product in Immunocytochemistry. FLCs are different from macrophages. B FLCs at passage 1 and Raw Scale bars, 50 mum. Fig 2 Virulent Yersinia becomes partially embedded within the macrophage plasma membrane.

Shown in the enlargements are bacteria partially enveloped within host membrane. The bacterium in panel b is indicated by an arrow. The arrow in the enlarged image indicates a bacterium distinct from an EEA1-staining compartment. The data shown is representative of 3 independent experiments with similar results using both RAW macrophages and murine peritoneal macrophages.

Scale bar, 30 mum. Figure 5 Microglial activation in whole-mount retina and microglial migration in an in vitro model. Representative images of spinal cord A - C and hippocampus D tissues are shown. Dotted white lines indicate tissue section edges.

White arrows indicate areas of colocalisation. Figure 8. Figure 4 Rb1 mitigates inflammation in Ang II-infused mice. DAPI in blue was counterstained to help visualize the nuclei. Scale bar, 50 mum. DAPI in blue counterstaining was performed to visualize the nuclei. Relative fold change was plotted against that from the sham controls. Figure 3 CD11b- and TLRactivated alveolar macrophages with an increased expression of the NF- kappa B p50 and p65 subunits in them are detected on the histological sections obtained from the lung tissues distant from tuberculomas d , but not from tuberculoma walls t for TB patients A The number of alveolar macrophages with the markers expressed as the percentage of the total number of the TB patients'' alveolar macrophages analyzed.

The expression of the markers is shown as in Figure 2 A. Red arrows indicate a trend in the alteration of the number of the markers-positive alveolar macrophages between various lung lesions of the same TB patients. Close-ups of the parts of these images with alveolar macrophages and other cells, with or without the examined markers in them, are shown in the corners.

The scale bars are 50 um for the histological sections and 10 um for the enlarged views of them. C , D The NF- kappa B subunits localize in the cytoplasm, but not in the nuclei of alveolar macrophages. White arrows point to alveolar macrophages used to create the profile images.

Red arrows identify the areas for the construction. A Heat-map of the down-regulated immunosuppressive cytokines in Fig. B Heat-map of the up-regulated immunostimulatory cytokines in Fig. C - J Immunohistochemical analysis of immune cell infiltration in tumors, as well as recruitment and activation in spleens. Nuclei is counterstained with DAPI blue. Scale bars, um. Shown is one of t. Figure 2 Transcriptomic profiling of pre-metastatic lungs demonstrates an inflammatory response and myeloid cell infiltration.

A Volcano plot of differentially expressed genes in pre-metastatic lungs compared to control lungs. Figure 3 Osteosarcoma cell-derived extracellular-vesicles EVs promote accumulation of bone marrow-derived cells in the lungs. A Schematic illustration of the experimental setup. Transcript levels are normalized to Gapdh and expressed as fold change relative to control mice. Scale bar, um. Haematoxylin and eosin stain. Tissue was collected on day 8 24 h after the third treatment.

Published figure using CD11b monoclonal antibody Product in Immunohistochemistry. Figure 6. Merged panels show colocalization of CD11b with the corresponding inflammatory marker. Scale bar: 40 mum. Figure 4. A Representative bands of Nrf2 immunostaining. B Quantitative data of Nrf2 immunostaining. D Quantitative data of double positive cells. E Representative bands of HO-1 immunostaining. H Quantitative data of double positive cells; I Representative bands of gp91phox immunostaining.

J Quantitative data of gp91phox immunostaining. L Quantitative data of double positive cells. Figure 3. C Representative bands of iNOS immunostaining. D Quantitative data of iNOS immunostaining. F Quantitative data of double positive cells. G Representative bands of Arg-1 immunostaining.

H Quantitative data of Arg-1 immunostaining. J Quantitative data of double positive cells. Figure 2. A Representative bands of TLR2 immunostaining. B Quantitative data of TLR2 immunostaining. H Quantitative data of double positive cells. Product Details. Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity. The orphan nuclear receptor EAR-2 NR2F6 inhibits hematopoietic cell differentiation and induces myeloid dysplasia in vivo. Adeno-associated viral AAV vectors do not efficiently target muscle satellite cells.

Ucp2-dependent microglia-neuronal coupling controls ventral hippocampal circuit function and anxiety-like behavior. Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury. Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss.

Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement. The armed oncolytic adenovirus ZDIL eradicates melanoma by turning the tumor cells from the self-state into the nonself-state besides direct killing. LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes. Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development. The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.

The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells. Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model.

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation. Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target. BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis.

Ly6c Lo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation. Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment. Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy. Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis.

Central nervous system regeneration is driven by microglia necroptosis and repopulation. Published figure using CD11b monoclonal antibody Product in Immunoprecipitation. Distinct Tie2 tyrosine phosphorylation sites dictate phenotypic switching in endothelial progenitor cells. Published figure using CD11b monoclonal antibody Product in Immunofluorescence.

Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses. Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes. The nuclear variant of bone morphogenetic protein 2 nBMP2 is expressed in macrophages and alters calcium response.

Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias. Simultaneous isolation of mesenchymal stem cells and endothelial progenitor cells derived from murine bone marrow. A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.

Analysis of leukocyte transepithelial migration using an in vivo murine colonic loop model. Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge. Elimination of intravascular thrombi prevents early mortality and reduces gliosis in hyper-inflammatory experimental cerebral malaria. Primary cilia disruption differentially affects the infiltrating and resident macrophage compartment in the liver.

Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease. MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis. Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.

Bone marrow niche trafficking of miR controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia. Investigation of tumor-tumor interactions in a double human cervical carcinoma xenograft model in nude mice.

A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. Pluripotency factors functionally premark cell-type-restricted enhancers in ES cells. Protection by and maintenance of CD4 effector memory and effector T cell subsets in persistent malaria infection.

MT4-MMP deficiency increases patrolling monocyte recruitment to early lesions and accelerates atherosclerosis. Published figure using CD11b monoclonal antibody Product in Neutralization. Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.

Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock. Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury. Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation. Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment.

Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice. Loss of epidermal AP1 transcription factor function reduces filaggrin level, alters chemokine expression and produces an ichthyosis-related phenotype. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma.

Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps. Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis. JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression. A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer. Sertoli cell condition medium can induce germ like cells from bone marrow derived mesenchymal stem cells.

Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPVdriven cervical tumorigenesis in vivo. IL induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL responses to skin immunization. The breast tumor microenvironment alters the phenotype and function of natural killer cells. Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury. Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice.

Stroke sensitivity in the aged: sex chromosome complement vs. Diet-dependent, microbiota-independent regulation of ILproducing lamina propria macrophages in the small intestine. Alternatively activated macrophages determine repair of the infarcted adult murine heart. Classical dendritic cells are required for dietary antigen-mediated induction of peripheral T reg cells and tolerance.

Acidic chitinase primes the protective immune response to gastrointestinal nematodes. Multimodal analysis of ocular inflammation using the endotoxin-induced uveitis mouse model. Irradiation of necrotic cancer cells, employed for pulsing dendritic cells DCs , potentiates DC vaccine-induced antitumor immunity against high-grade glioma. Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice.

Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination. Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies.

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